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simple grinding method in chemistry

simple grinding method in chemistry. simple grinding method in chemistry. Popular Searches. Learn Chemistry. Nov 19, 2019· Chemistry is a logical science You can master the essential concepts yourself You can study these concepts in any order, but it''s probably best to start from the top and work your way down, since many concepts build on understanding units, …

Comparative Study of Chemical Synthesis of Pyrimidine ...

conventional method and Grindstone chemistry Technique . Melting points were determined in open capillary tubes on a Buchi 530 melting point apparatus. The IR spectra were recorded on Shimadzu 435 FT - IR spectrophotometer with samples prepared as …

Comparative Study of Chemical Synthesis of Pyrimidine ...

The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH 4 Cl ...

p-Toluenesulfonic Acid (p-TSA) Catalyzed Efficient ...

When compared to the other reported methods, we have found that p-TSA in solvent-free condition is found to be an efficient catalyst for the synthesis of bis (indolyl) methanes under Grindstone method.The reaction of indole with aldehydes and ketones proceeds smoothly at room temperature to afford the corresponding bis (indolyl) derivatives in high yields in a short …

Synthesis, antibacterial studies, and molecular modeling ...

2015-7-4 · The syntheses of dihydropyrimidinones (DHPMs) using solvent-free grindstone chemistry method. All the synthesized compounds exhibited significant activity against pathogenic bacteria. The current effort has been developed to obtain new DHPM derivatives that focus on the bacterial ribosomal A site RNA as a drug target. Molecular docking simulation analysis was …

An Operationally Simple and Efficient Synthesis of 7 ...

2021-7-21 · Results and Discussion: The notable advantages of this method include mild synthetic conditions, weak acid catalysis, and non-hazardous solvent which make this method environmentally safer. Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for the synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7 ...

Fe3O4-CNTs nanocomposites: a novel and excellent …

employed in the Biginelli reaction under grindstone method Results and discussion In order to synthesize dihydropyrimidinone derivatives, we focused our attention on Biginelli-type cyclocondensation of aromatic aldehydes with urea and aromatic ketones. For the first time, an easily accessible and stable catalytic system has

Synthesis, antibacterial studies, and molecular modeling ...

2015-7-4 · Jayakumar S, Shabeer TK. Multicomponent Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones by grindstone technique and evaluation of their biological properties. J Chem Pharm Res. 2011; 3 (6):1089–1096. [Google Scholar]

Green preparation and structure elucidation of spiro ...

2017-8-3 · Grindstone Chemistry technique or Toda''s solvent-free green method of grinding reactants together has been successfully applied for conducting multicomponent reaction of 1H-indole-2,3-dione, malononitrile and 2-thioxo-4-thiazolidinone for the synthesis of Spiro indole derivatives. The reaction conditions have been studied and compared with conventional …

Multicomponent synthesis of 4-arylidene-2-phenyl-5(4H ...

2016-10-6 · Mechano heterocyclic chemistry (MCH) is a recent quickly growing technique in the synthesis of heterocycles and draws the attention of heterocyclic chemists towards the uses of grindstone technique in a solvent free green efficient synthesis of many heterocyclic systems. On the other hand, multicomponent approach has opened the door for the rapid and efficient one …

A simplified green chemistry approach to the Biginelli ...

2004-11-1 · Grindstone Chemistry––a greatly evolved version of Toda''s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.

Rapid synthesis of 1,6-naphthyridines by grindstone ...

2015-1-24 · Many methods to prepare heterocyclic compounds involve toxic solvents and reagents. There is therefore a need to design cleaner synthetic procedures. 1,6-Naphthyridine derivatives are used in many applications such as cancer chemotherapy, antibacterials, antivirals and antiproliferatives. Here, we report the solvent-free and catalyst-free synthesis of 1,6 …

Solvent-Free Heterocyclic Synthesis | Chemical Reviews

2009-9-9 · Solvent-Free and Catalyst-Free Biginelli Reaction To Synthesize Ferrocenoyl Dihydropyrimidine and Kinetic Method To Express Radical-Scavenging Ability. The Journal of Organic Chemistry 2012, 77 (8), 3952-3958. DOI: 10.1021/jo300282y.

Lithium-Acetate-MediatedBiginelliOne-Pot ...

2019-7-31 · Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent- ... the present method has advantages of good yields, short reaction times, and experimental simplicity. The obtained ... a technique known as "grindstone chemistry," ...

(DOC) Title: Experiment 1 Synthesis of ...

Grindstone Chemistry––a greatly evolved version of Toda''s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the ...

Multicomponent mechanochemical synthesis

2018-2-28 · The method normally gave excellent results, ... Singh and co-workers have proposed SnCl 4 ·5H 2 O as a Lewis acid catalyst for the "grindstone" Biginelli reaction.53. A number of ball-milling studies have also been performed, focused on the planetary milling approach.

Multicomponent mechanochemical synthesis

The method normally gave excellent results, ... Singh and co-workers have proposed SnCl 4 ·5H 2 O as a Lewis acid catalyst for the "grindstone" Biginelli reaction. 53. A number of ball-milling studies have also been performed, …

A Facile Biginelli Reaction on Grinding Using Nano …

2014-8-21 · the methods belonging to such a protocol is grindstone method. This mechanically activated solvent-free reaction helps in reducing the toxic waste produced, and therefore, becomes less harmful to the environment [4]. In this study, we report our results for the DHPMs using MCM-41-SO3H under solvent free conditions by grinding. 2. EXPERIMENTAL

Biginelli Reaction Mediated Synthesis of Antimicrobial ...

2021-10-4 · 2. Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives. Kidwai et al. developed a convenient synthetic route for the preparation of quinazolines 2a–2h by heating equimolar amounts of aldehyde 1a–1d, 5,5-dimethyl-1,3-cyclohexanedione (dimedone), and urea/thiourea in the absence of solvent and catalyst, under microwave irradiation …

Prof. Suhas Pednekar

2021-12-12 · Prof. Suhas Pednekar - Publications - This is personal home page of Dr. Suhas Pednekar, Professor of Chemistry & Principal, Ramnarain Ruia College, Matunga, Mumbai. He is also a researcher, an organic chemist and is mainly intrested in areas of Green Chemistry.

Multicomponent biginelli synthesis of …

2021-3-19 · Multicomponent Biginelli Synthesis of 3,4-dihydropyrimidin-2(1 H)-ones by grindstone technique and evaluation of their biological properties. S. Jayakumar and T. K. Shabeer * Department of Chemistry, Gojan School of Business and technology, Chennai, T.N., INDIA *P.G. and Research Department of Chemistry, The New College, Chennai, T.N., INDIA

Mechanochemistry: An efficient method of solvent-free ...

application of grindstone method is evident from the fact that, many reactions like Reformatsky reaction (Tanaka et al., 1991), Aldol condensation (Toda et al., 1990), Dieckmann condensation (Toda et al., 1998), Knoevenagel condensation (Ren et …

Microwave initiated reactions: Pechmann coumarin …

2010-10-29 · In an earlier publication, we described the ''Grindstone Chemistry'' method for conducting exothermic reactions in the solvent-free mode.3 When this protocol was ap-plied to the Pechmann synthesis on a multi-molar scale, the expected coumarins were obtained in a few minutes as pure products in high yield by solvent-free grinding.

A highly efficient one-pot multicomponent synthesis of 3,4 ...

2020-9-15 · The Biginelli reaction is a method for the synthesis of DHPMs in one-step process. Several metal oxides as nanocatalysts have been used in Biginelli reactions summarized in Refs. [,,,,,, ]. The aim of the present work is the introduction of a novel synthesis procedure for the synthesis of Sr 2 As 2 O 7 nanomaterials.

Synthesis, antibacterial studies, and molecular modeling ...

The syntheses of dihydropyrimidinones (DHPMs) using solvent-free grindstone chemistry method. All the synthesized compounds exhibited significant activity against pathogenic bacteria. The current effort has been developed to obtain new DHPM derivatives that focus on the bacterial ribosomal A site RNA as a drug target. Molecular docking simulation analysis was applied to …

A simplified green chemistry approach to the Biginelli ...

Abstract Grindstone Chemistry––a greatly evolved version of Toda''s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.

Phosphate functionalized graphene oxide with enhanced ...

2018-1-1 · Similarly, solid state grindstone method was also employed for the synthesis of DHPM. In both the cases, the product yield was found to be very less ( Table 2 ). The best result was obtained in microwave assisted synthesis where the reaction time was considerably lower, resulting high product yield (94%) (entry 4, Table 2 ).

Recent advances in catalysts immobilized on magnetic ...

2016-6-22 · Ketone instead of 1,3-dicarbonyl compounds employed in the Biginelli reaction under grindstone method. Full size image. Ionic liquids immobilized on magnetic nanoparticles. Ionic liquids (ILs) are increasingly being explored for targeted chemical tasks due to their unique chemical and physical properties of nonvolatility, ...

Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ketone ...

In this study, SbCl3 as catalyst to benzaldehyde, ethyl acetoacetate and urea as raw material in the ultrasonic radiation synthesis of 3,4-Dihydropyrimidin-2(1H)-ketone. According to the orthogonal design optimization experiment, optimization method ultrasonic extraction technology, and ultimate pass to get the best synthetic condition for: material ratio 1.0,1.0,1.5(mol), …

A simplified green chemistry approach to the Biginelli ...

Grindstone Chemistry––a greatly evolved version of Toda''s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.

Lithium-acetate-mediated Biginelli one-pot …

2012-4-19 · Various Biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent-free, and eco-friendly conditions in a one-pot reaction of 1,3-dicarbonyl compounds, aldehydes, and urea/thiourea/acetyl thiourea using lithium-acetate as a novel catalyst without the addition of any proton source.

Hydrothermal synthesis, characterization and catalytic ...

La3+ and Sm3+ - doped Bi2Mn2O7 nanocatalysts were synthesized in 1 M NaOH aqueous solution, via a stoichiometric 1:1 Bi:Mn molar ratio hydrothermal method at 180 °C for 48 h. Bi(NO3)3, MnO2, La(NO3)3 and Sm2O3 were used as raw materials. The synthesized nanomaterials were characterized by powder X-ray diffraction (PXRD) technique. Both of the …